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Principipal Investigators in the consortiumP02: NELLEN, Wolfgang & HAMMANN, Christian (Kassel, GERMANY) Wolfgang Nellen is full professor of genetics at UniK since 8 years and director of the Institute of Biology since 2003. Before, he had 15 years of postdoctoral experience, 9 of these as an independent group leader at the Max-Planck-Institute for Biochemistry (Martinsried). The research of his team focuses on the molecular biology of RNA and biophysical approaches to study RNA-protein interaction. The laboratory has contributed to the understanding of RNA mediated gene silencing by antisense RNA and, more recently, RNAi. Within the last 3 years, more than 15 putative or confirmed components of RNA mediated gene regulation have been identified in the laboratory and are currently under thorough investigation. With 20 years of experience with Dictyostelium, the laboratory has all the available molecular and genetic tools for this model organism at hand. Since 4 years, scanning force microscopy to investigate RNA-protein interactions has been established. The laboratory is member of the Center for Interdisciplinary Nanostructure Science and Technology (CINSaT). Christian Hammann is a research associate in the GG with 5 years of postdoctoral experience and leader of an independent research group. His expertise is in the fields of RNA biochemistry and biophysics that he established in previous work on hammerhead ribozymes. UniK is a state university with a full Natural Science Faculty consisting of Institutes of Biology, Chemistry and Physics with 12, 5 and 11 research groups respectively. 8 of these groups with approx. 60 scientific personnel concentrate on different fields of molecular biology. Facilities for DNA sequencing, monoclonal antibody production, protein purification, microcalorimetry, scanning force-, confocal- and electron- microscopy are available. Relevant for this application is the close in-house cooperation with the Cell Biology group that has excellent experience with confocal microscopy on Dictyostelium cells and with the Developmental Biology group that has a fully set up Drosophila laboratory. All the necessary instruments and infrastructure to carry out the proposed project are provided. CINSaT, the recently founded interdisciplinary scientific priority center at UniK provides further technical support by e.g. a state-of-the-art central facility for mass spectroscopy that is currently being established.
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