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Principipal Investigators in the consortiumP08: FILIPOWICZ, Witold (Basel, SWITZERLAND) Witold Filipowicz is Professor of Biochemistry, a Senior Staff Scientist at the FMI since 1984. He is also a Titularprofessor at the Biozentrum of the Basel University, and Professor at the Institute of Biochemistry and Biophysics, Polish Academy of Sciences in Warsaw. He is a member of EMBO, and of Editorial Boards of several journals including two focused on RNA: RNA and RNA biology (to be launched in January 2004). Filipowicz’s group has over two decades of experience with working on different classes of eukaryotic non-coding RNAs, and respective ribonucleoproteins (RNPs). It significantly contributed to the understanding of biogenesis, structure and function of mammalian RNPs such as RNase MRP, telomerase, and the H/ACA class guide snoRNPs, and also studied non-coding polyA+ RNAs hosting guide snoRNAs in their introns. The group has also long-standing interest in enzymology and structure of enzymes involved in RNA metabolism. Its work led to the discovery and/or establishment of 3D structures of enzymes such as tRNA splicing ligase, the RNA 3’-phospate cyclase, and cyclic nucleotide 3’-phosphodiestarase. FMI is one of the leading European institutions devoted to research on epigenetics and cancer. Facilities of the FMI include state-of–the-art sequencing, transcriptome, proteomics, knock-out mice, monoclonal, and histology cores, and the group has all the necessary expertise in the fields of protein and RNA biochemistry, cell culture, protein and RNA visualisation by immunofluorescence, immunocytochemistry, and in situ hybridisation. It also has experience and appropriate permits to work with mice and mouse embryo cultures in vitro. Over 20 independent groups (approx. 250 people) are working in the FMI in areas of gene expression, cancer, epigenetics and neurobiology (including other groups interested in RNAi/miRNAs), creating a very stimulating multidisciplinary environment.
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