Publications P08 FILIPOWICZ

2008

Sinkkonen L. Hugenschmidt T. Berninger P. Gaidatzis D. Mohn F. Artus-Revel C. Zavolan M. Svoboda P. Filipowicz W. (2008) MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nature Str. Mol, Biol., published on-line on March 2, 2008.

Filipowicz W. Bhattacharyya SN. Sonenberg N. (2008) Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nature Rev. Gen. 9, 102-114.

2007

Mathonnet G. Fabian MR. Svitkin YV. Parsyan A. Huck L. Murata T. Biffo S. Merrick WC. Darzynkiewicz E. Pilai R. Filipowicz W. Duchaine TF. Sonenberg N. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex elF4F. Science 317, 1764-1767

Jasiewicz L and Filipowicz W. Role of Dicer in post-transcriptional RNA silencing. Current Topics in Microbiology, in press.

Bhattacharyya SN and Filipowicz W. (2007) Argonautes and Company: Sailing against the wind. Cell 128, 1027 – 1028

Beuvink I, Kolb FA, Budach W, Garnier A, Lange J, Natt F, Dengler U, Hall J, Filipowicz W and Weiler J. (2007) A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs. Nucleic Acid Research, 35, e52 (Epub March 13, 2007)

Pillai RS, Bhattacharyya SN and Filipowicz W. (2007) Repression of protein synthesis by miRNAs: How many mechanisms? Trends in Cell Biology 17, 118 – 126

2006

Putics Á, Slaby J, Filipowicz W, Gorbalenya A, and Ziebuhr J. ADP-ribose-1"-phosphatase activities of the human coronavirus 229E and SARS coronavirus X domains. Adv Exp Med Biol. 581: 93-96.

Schmitter D, Filkowski J, Sewer A, Oakeley EJ, Zavolan M, Svoboda P, and Filipowicz W (2006) Analysis of transcripts regulated by Dicer and Argonaute proteins suggests buffering role of miRNAs in human HEK293 cells, Nucleic Acid Research, 34:4801-4815.

Bhattacharyya S, Habermacher R, Martine U, Closs EI and Filipowicz W. (2006) Stress induced reversal of miRNA repression and mRNA P-body localization in human cells. In “Regulatory RNAs”, Cold Spring Harb. Symp. Quant. Biol. 71: 513 - 521

Bhattacharyya S, Habermacher R, Martine U, Closs EI and Filipowicz   W Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 125, 1111 – 1124 (2006)

Kotaja N., Bhattacharyya S., Jaskiewicz L., Kimmins S., Parvinen M., Filipowicz W., and Sassone-Corsi P. The chromatoid body of male germ cells: similarity with P-bodies and presence of Dicer and microRNA pathway components. Proc. Nat.  Acad. Sci. USA. 103, 2647-2652.

2005

Pellino, J., Jaskiewicz, L., Filipowicz, W., and Sontheimer. ATP modulates siRNA interactions with an endogenous human Dicer complex. RNA 11: 1719-24 (2005).

Putics, Á., Filipowicz, W., Hall, J., Gorbalenya, A., and Ziebuhr, J. ADP-ribose-1"- monophosphatase: a conserved coronavirus enzyme that is dispensible for viral replication in tissue culture. J. Virol. 79: 12721-31 (2005).

Haase, A., Jaskiewicz, L., Zhang, H., Lainé, S., Sack, R., Gatignol, A., and Filipowicz, W. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Reports. 6: 961-7  (2005)

Pillai, R., Bhattacharyya, S., Artus, C., Zoller, T., Cougot, N., Basyuk, E., Bertrand,  E., and Filipowicz, W. Inhibition of translational initiation by let-7 microRNA in human cells. Science. 309:1573-6 (2005)

Filipowicz, W. RNAi: The nuts and bolts of the RISC machine. Cell. 122, 17-20 (2005)

Filipowicz, W., Jaskiewicz, L., Kolb, F., and Pillai, R. Post-transcriptional gene silencing by siRNAs and miRNAs. Curr. Op. in Cell Biol. 15, 1-11 (2005)

Westhof, E., and Filipowicz, W. From RNAi to epigenomes: how RNA rules the world. ChemBioChem (European Journal of Chemical Biology) 6, 441-3 (2005)

Kolb, FA., Zhang, H., Jaronczyk, K., Tahbaz, N., Hobman, TC., and Filipowicz, W. Human Dicer: Purification, properties and interaction with PAZ PIWI domain Proteins. Meth. Enzymol., 392, 316-336 (2005)

2002

Zhang, H., Kolb, F.A., Brondani, V., Billy, E. and Filipowicz, W. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21, 5875-5885 (2002).

2001

Billy, E., Brondani, V., Zhang, H., Müller, U. and Filipowicz, W. Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci USA 98, 14428-14433 (2001).

2000

Dragon, F., Pogacic, V. and Filipowicz, W. In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol. Cell. Biol. 20, 3037-3048 (2000).

Pogacic, V., Dragon, F. and Filipowicz, W. Human H/ACA small nucleolar RNPs and telomerase share evolutionary conserved proteins NHP2 and NOP10. Mol. Cell. Biol. 20, 9028-9040 (2000).

Filipowicz, W., Imprinted expression of small nucleolar RNAs in brain: Time for RNomics. Proc Natl Acad Sci USA 97, 14035-14037 (2000).